Specific protein assays
Your partner in targeted protein analysis
Introduction
What are specific protein assays?
Specific protein assays determine the amount or concentration of a specific protein or an array of different proteins in a sample.
Different assays in this group may aid in the characterization of a number of disorders. Individual assays in this group may aid in the characterization of:
- Chronic heart diseases
- Autoimmune disorders
- Infections
- Hemolytic diseases (anemias)
- Metabolic disorders and other diseases
Optilite® Analyser provides automated specific protein assays with enhanced efficiency and optimized workflow
Range of assays
The following assays are included in the specific protein assay range
Cardiac assays
- Apolipoprotein A1 and B
- High sensitive C-reactive protein
- Lipoprotein (a)
Inflammation assays
- A1 Acid Glycoprotein
- A1 Antitrypsin
- ASO
- CRP
- Rheumatoid factor
Other assays
- Caeruloplasmin
- Haptoglobin
- Prealbumin
- Tetanus Toxoid**
- Total Protein
- Transferrin
| **Automated assay unique to Binding Site. Abbreviation: ASO - Antistreptolysin O; CRP – C-reactive protein |
- Apolipoprotein A1 & B
- Measurement of Apo A1 and B levels can aid in the assessment of cardiovascular disease and lipoprotein metabolism disorders
- Apo A1 can aid in the assessment of risk of atherosclerotic cardiovascular disease
- Lipoprotein (a)
- Assessment of lipid disorders
- Assessment of risk of atherosclerotic cardiovascular disease
- Measurement of Lp(a), alongside LDL-cholesterol, HDL-cholesterol, apolipoprotein A-1 and apolipoprotein B, is a valuable tool in evaluation of CHD
- High sensitive C-reactive protein (hs CRP)
- hsCRP can aid in identification of inflammation
With regard to lipoprotein (a), the European Atherosclerosis Society recommends measurements in molar (nmol/L) scale rather than mass scale (g/L).1 As such, the Binding Site lipoprotein (a) assay measures lipoprotein (a) in nmol/L.
- Anti-Streptolysin O (ASO)- Can be used to establish the degree of infection past or present, by β-haemolytic streptococci
- Rheumatoid Factor (RF)- A marker that may aid in the characterisation of rheumatoid arthritis
- ɑ1 Acid Glycoprotein & C Reactive Protein are acute phase reactants raised in acute & chronic inflammatory conditions
- ɑ1 Antitrypsin deficiency may lead to conditions like pulmonary emphysema
- High sensitive C-reactive protein (hs CRP) can aid in identification of inflammation
- Anti-tetanus toxoid - Quantitatively measures anti-tetanus antibodies in EDTA plasma or serum
- Haptoglobin - A diagnostic marker for hemolytic diseases such as anemia, liver disease and inflammatory conditions
- Caeruloplasmin - A diagnostic marker for copper metabolism disorders, such as Menkes or Wilson’s disease
- Prealbumin - Helps in determination of nutritional status
- Total protein - Measurement of total proteins in blood can aid in detection of disorders such as:
- Hypoproteinemia (which may be due to defective protein synthesized in the liver, protein loss due to impaired kidney function, intestinal malabsorption or nutritional deficiency)
- Hyperproteinemia (which may be due to chronic inflammatory disorders, liver cirrhosis and dehydration)
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References
1. Nordestgaard, B.G., Chapman, M.J., Ginsberg, H.N., The European Atherosclerosis Society Consensus Panel. (2012). Lipoprotein(a): EAS recommendations for screencing, desirable levels and management