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Paraprotein QA Scheme

Quality Assurance Scheme for free light chain analysis

It is essential that all laboratories participate in external quality control schemes when performing monoclonal protein analysis.

Binding Site IMMPROVE™ Serum Paraprotein QA Scheme - QA 003

Around 300 laboratories worldwide participate in the Serum Paraprotein scheme currently. Methodologies include Serum Protein Electrophoresis (SPE), Immunofixation Electrophoresis (IFE) and a large range of nephelometric and turbidimetric Freelite® free light chain assays. Laboratories are able to return quantitative results for the analysis of IgG, IgA, IgM, B2 microglobulin, Freelite free kappa, free lambda and determination of the free kappa/lambda ratio.

Freelite® serum free light chain analysis

Four samples are issued per year and results can be returned via the IMMPROVE website. A comprehensive report is returned to each laboratory and includes photocopies of electrophoresis gels, comparisons with other laboratories' results and an expert opinion regarding the sample and results.

Participants will be able to view their Bias Index Score (BIS), Variable Index Score (VIS), Mean Running Bias Index Score (MRBIS) and Mean Running Variable Index Score (MRVIS) for both the specific method and the overall statistics.

Example results are shown for the serum sample in QA003 distribution number 111.

QA003 Results

Binding Site IMMPROVE™ Urine Paraprotein QA Scheme - QA 006

Two urine samples are issued per year for quality assurance of quantitative results for Freelite® free Kappa, Free Lambda and free kappa/lambda ratio in Urine on a range of nephelometric and tubidimetric assays. In addition qualitative paraprotein results for urine protein electrophoresis and urine Immunofixation electrophoresis can be quality assured.