Anti β2GP1 IgM S Kit
Antiphospholipid antibodies are associated with diseases such as systemic lupus erythematosus (SLE) and more specifically in patients with antiphospholipid syndrome (APS). This anti ß2GP1 EIA kit is designed for the detection and accurate quantitation of IgM class autoantibodies against ß2GP1 in human serum samples.
Antigen
The microwells are precoated with purified ß2GP1.
Calibration
The assays are calibrated against the Sapporo HCAL monoclonal standard1.
The Standardization Committee of the European Forum for Antiphospholipid Antibodies have supported the introduction of the Sapporo HCAL and EY2C9 IgG and IgM reference preparations. These standards are monoclonal antibodies that have dual functionality for both cardiolipin and β2GP-1 (results expressed in μg/mL). The monoclonal nature of these standard preparations ensures reproducibility1-3.
A 5 point calibration curve is generated.
Result Interpretation
| Result | Interpretation |
|---|---|
| < 10 U/mL | Negative |
| > 10 U/mL | Positive |
Measuring Range
3.7 - 300 U/mL
References
1. Cervera, R. et al. V Meeting of the European Forum on Antiphospholipid Antibodies. Autoimmunity Rev 2006;5:499-507
2. Fontain, M. et al. Persistent Problems with Standardization of Immunoassays for Anti-Cardiolipin Antibodies Thromb Haemost 2001; 86:1123-1124
3. Tincani, A. et al. Anticardiolipin Antibody Assay: a Methodological Analysis for a better Consensus in Routine Determinations. A Cooperative Project of the European Antiphospholipid Forum. Thromb Haemost 2001; 86 575-583
- Download Literature - Anti-Cardiolipin and Anti-β2 Glycoprotein-1 S Range EIA - Code MKG444
- Download German Literature - Anti-Cardiolipin and Anti β2 Glycoprotein-1 S Range EIA - Code MKG471
- Download French Literature - Anti-Cardiolipin and Anti β2 Glycoprotein-1 S Range EIA - Code MKG483
- Download Poster - Performance of an IgG and IgM anti-β2GP1 assay calibrated to the chimeric monoclonal Sapporo reference preparations, HCAL and EY2C9 - Code MKG457
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